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News/Information/Articles |
 Diazepam tolerance and physical dependence
Diazepam tolerance and physical dependence
Diazepam as with other benzodiazepine drugs can cause tolerance, physical dependence, ...
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Arrest Made in Princeton,West Virginia Drug Bust.
The Princeton City,West Virginia Police Department made the arrest Thursday morning.
PRINCETON,West Virginia -- ...
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Side effects of Diazepam
Side effects of Diazepam
Diazepam has a range of side effects which are common to most ...
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Man robs two drug stores for power painkiller.
TRACY,California – A man today robbed at gunpoint two Tracy drug stores of a power ...
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Diazepam
Diazepam
Diazepam was first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine derivative drug. It ...
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OxiContin the drug of choice of abusers.
Jacksonville,Florida police say tracking down prescription drug’s source is difficult
When it comes to the abuse ...
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Pharmacy robbed for fourth time.
Man gets away with brand-name OxyContin pills.
The robber walked into Hunnington,Alabama Pharmacy on South ...
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Restoril tolerance and dependence
Restoril tolerance and dependence
Chronic or excessive use of Restoril may cause drug tolerance, which can ...
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ID theft ring linked to meth.
JEFFERSON COUNTY,Colorado - A grand jury has indicted six people for operating an identity ...
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Acute effects of drug addiction
Acute effects of drug addiction
Acute (or recreational) drug use causes the release and prolonged action ...
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Drug addiction behavior
Drug addiction behavior
Understanding how learning and behavior work in the reward circuit can help understand ...
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Stress response
Stress response
In addition to the reward circuit, it is hypothesized that stress mechanisms also play ...
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Long-term use of Vicodin can also lead to physical dependence and addiction
A severe overdose of Vicodin can be fatal
Individuals with a Vicodin addiction become deeply depressed, and their thinking, attention, and judgment become impaired.
Vicodin is a derivative of opium, which is also used to manufacture heroin.
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Diazepam
Diazepam
Diazepam was first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, sedative, skeletal muscle relaxant and amnestic properties. It is commonly used for treating anxiety, insomnia, seizures, alcohol withdrawal, and muscle spasms. It may also be used before certain medical procedures (such as endoscopies) to reduce tension and anxiety, and in some surgical procedures to induce amnesia.
Diazepam is a core medicine in the World Health Organization's "Essential Drugs List", which is a list of minimum medical needs for a basic health care system. Diazepam is used to treat a wide range of conditions and has been one of the most frequently prescribed medications in the world for the past 40 years. It was first synthesized by Dr. Leo Sternbach.
Diazepam was the second benzodiazepine to be invented by Sternbach of Hoffmann-La Roche, and was approved for use in 1963. It is two and a half times more potent than its predecessor, chlordiazepoxide, which it quickly surpassed in terms of sales. After this initial success, other pharmaceutical companies began to introduce other benzodiazepine derivatives.
The benzodiazepines gained popularity among medical professionals as an improvement upon barbiturates, which have a comparatively narrow therapeutic index, and are far more sedating at therapeutic doses. The benzodiazepines are also far less dangerous; death rarely results from diazepam overdose, except in cases where it is consumed with large amounts of other depressants (such as alcohol or other sedatives).
Diazepam was the top-selling pharmaceutical in the United States from 1969 to 1982, with peak sales in 1978 of 2.3 billion tablets. Diazepam along with oxazepam, nitrazepam and temazepam represent 82% of the benzodiazepine market in Australia. While psychiatrists continue to prescribe diazepam for the short-term relief of anxiety, neurology has taken the lead in prescribing diazepam for the palliative treatment of certain types of epilepsy and spastic activity, e.g., forms of paresis. It is also the first line of defense for a rare disorder called stiff-person syndrome.
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